Aquaporin 2 Antibody
Product Sizes
100 ul
£587.00
OAPC00158-100UL
About this Product
- SKU:
- OAPC00158
- Additional Names:
- AQP-2; aquaporin-2
- Clonality:
- Polyclonal
- Concentration:
- 0.52 mg/ml
- Extra Details:
- Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.;2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al.; 2002). Recently; serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al.; 2007).
- Host:
- Rabbit
- Immunogen:
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin 2.
- Molecular Weight:
- ~29 kDa
- Protein Details:
- Aquaporin-2
- Purification:
- The antibody is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage -80°C is recommended; but shorter term storage at -20°C is also acceptable as aliquots may be taken without freezing/thawing due to the presence of 50% glycerol. Stock solutions are stable for a minimum of 1 year at -20°C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
