Anti-GABA Alpha Receptor; Gamma 2 -Subunit
Product Sizes
50 ul
£543.00
OAPC00122-50UL
About this Product
- SKU:
- OAPC00122
- Clonality:
- Polyclonal
- Extra Details:
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system; causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative; anxiolytic; and hypnotic agents and are implicated in several diseases including epilepsy; anxiety; depression; and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alpha s; four beta s and four gamma s; plus alternative splicing variants of some of these subunits; have been identified (Olsen and Tobin; 1990; Whiting et al.; 1999; Ogris et al.; 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha - and beta -subunits results in the expression of functional GABAA-Rs sensitive to GABA. However; co-expression of a gamma -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha -subunits of the receptor (McKernan et al.; 2000; Mehta and Ticku; 1998; Ogris et al.; 2004; Pöltl et al.; 2003). Lastly; phosphorylation of beta -subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al.; 2003).
- Host:
- Rabbit
- Immunogen:
- Peptide representing a sequence that is specific for the gamma 2-subunit of rat GABAA receptor. The sequence of the immunogen has no homology with any other GABAA R-subunit.
- Molecular Weight:
- ~46kDa
- Protein Details:
- Gamma-aminobutyric acid receptor subunit gamma-2
- Purification:
- Unpurified neat serum.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
