Anti-Glyceraldehyde 3-Phosphate Dehydrogenase
Product Sizes
100 ul
£587.00
OAPC00113-100UL
About this Product
- SKU:
- OAPC00113
- Additional Names:
- GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278
- translate.label.attr.clone:
- 1D4
- Clonality:
- Monoclonal
- Extra Details:
- Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway; the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH is a protein expressed in large amounts and which is required at all times for important "house keeping" functions; levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly; scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. This antibody can be used as a loading control for western blotting experiments; allowing comparison between the level of this protein and others in a cell or tissue. Apart from a role in glycolysis; GAPDH may have other roles such as in the activation of transcription (1). GAPDH is reported to bind to a variety of other proteins; including the amyloid precursor protein; mutations in which cause some forms of Alzheimer's disease; and the polyglutamine tracts of Huntingtin; the protein product aberrant forms of which are causative of Huntington's disease (2;3). Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis; and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic (4).
- Host:
- Mouse
- Immunogen:
- Extensively purified pig GAPDH.
- Isotype:
- IgM
- Molecular Weight:
- ~38kDa
- Protein Details:
- Glyceraldehyde-3-phosphate dehydrogenase; testis-specific
- Purification:
- Unpurified; concentrated culture supernatant.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C in undiluted aliquots; stable for up to one year after date of receipt. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
