Anti-Fibrillarin
Product Sizes
100 ul
£522.00
OAPC00110-100UL
About this Product
- SKU:
- OAPC00110
- Additional Names:
- LOT3
- translate.label.attr.clone:
- 38F3
- Clonality:
- Monoclonal
- Extra Details:
- Nop1p was originally identified as a nucleolar protein of bakers yeast; Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5kDa); is essential for yeast viability; and is localized in the nucleoli (1). The systematic name for S. cerevisiae Nop1 is YDL014W; and it is now known to be part of the small subunit processome complex; involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin (2). Fibrillarin/Nop1p is extraordinarily conserved; so that the yeast and human proteins are 67% identical; and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality; although mice with only one functional fibrillarin/Nop1p gene were viable (3). This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6).
- Host:
- Mouse
- Immunogen:
- Yeast nuclear preparations.
- Isotype:
- IgG<sub>1</sub>
- Molecular Weight:
- ~34kDa
- Protein Details:
- rRNA 2'-O-methyltransferase fibrillarin
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
