Anti-DARPP-32
Product Sizes
100 ul
£587.00
OAPC00098-100UL
About this Product
- SKU:
- OAPC00098
- Additional Names:
- Darpp32; Darpp-32
- Clonality:
- Polyclonal
- Extra Details:
- DARPP-32 is a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al.; 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast; when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al.; 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition; the activity of DARPP-32 is also thought to play important roles in the actions of alcohol; caffeine and Prozac (Maldve et al.; 2002; Lindskog et al.; 2002; Svenningsson et al.; 2002).
- Host:
- Rabbit
- Immunogen:
- Peptide corresponding to amino acid residues from the N-terminal region of rat DARPP-32; conjugated to keyhole limpet hemocyanin (KLH).
- Molecular Weight:
- ~32kDa
- Protein Details:
- Protein phosphatase 1 regulatory subunit 1B
- Purification:
- Prepared from rabbit serum by affinity purification via chromatography on an affinity column prepared with the N-terminal peptide used as antigen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C; stable for at least one year.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
