Anti-Synaptojanin I
Product Sizes
100 ul
£587.00
OAPC00065-100UL
About this Product
- SKU:
- OAPC00065
- Clonality:
- Monoclonal
- Extra Details:
- Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons; and the other ~ 170 kDa which is expressed in non-neuronal; peripheral tissues (Ramjaun AR & McPherson PS; 1996). The gene which encodes Synaptojanin 1; SYNJ1; has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4;5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al.; 2008).
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to amino acid residues from the C-terminal region of rat synaptojanin 1.
- Isotype:
- IgG
- Molecular Weight:
- ~145kDa
- Protein Details:
- Synaptojanin-1
- Purification:
- Protein G purified culture supernatant.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
