Anti-Rhodopsin
Product Sizes
100 ul
£587.00
OAPC00059-100UL
About this Product
- SKU:
- OAPC00059
- translate.label.attr.clone:
- 1D4
- Clonality:
- Monoclonal
- Extra Details:
- Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde; the oxidized form of retinol; to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies; disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al.; 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness; mainly due to constitutive activation; when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.;1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking; dysregulative activation; rod outer segment instability and arrestin binding.
- Host:
- Mouse
- Immunogen:
- Bovine rhodopsin.
- Isotype:
- IgG<sup>1</sup>
- Molecular Weight:
- ~39kDa
- Protein Details:
- Rhodopsin
- Purification:
- Protein G purified culture supernatant.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C in undiluted aliquots; stable for up to one year after date of receipt. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
