Anti-NMDA Receptor; NR1 Subunit; C2 Splice Variant Insert
Product Sizes
25 ug
£587.00
OAPC00041-25UG
About this Product
- SKU:
- OAPC00041
- Additional Names:
- NR1; GluN1; NMDAR1
- Clonality:
- Polyclonal
- Extra Details:
- The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory; neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's; epilepsy and ischemic neuronal cell death (Grosshans et al.; 2002; Wenthold et al.; 2003; Carroll and Zukin; 2002). There are a number of different splice variants of the NR1 subunit (Foldes et al.; 1994; Zukin and Bennett; 1995). Differential splicing of three exons in the NR1 subunit generates up to eight NR1 subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
- Host:
- Rabbit
- Immunogen:
- Peptide from the NR1 subunit; C2 splice variant insert of rat NMDA receptor.
- Molecular Weight:
- ~120kDa
- Protein Details:
- Glutamate receptor ionotropic; NMDA 1
- Purification:
- Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year. The antibody should be reconstituted
in 50 ul phosphate buffered saline (PBS: 137 mM NaCl; 7.5 mM Na2HPO4; 2.7 mM KCl; 1.5 mM KH2PO4; pH 7.4) before use. After
reconstitution the antibody should be aliquoted and stored at -20C. - Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
