Anti-NMDA Receptor; NR2C Subunit
Product Sizes
10 ug
£587.00
OAPC00036-10UG
About this Product
- SKU:
- OAPC00036
- Additional Names:
- NR2C; GluN2C
- Clonality:
- Polyclonal
- Extra Details:
- The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory; neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's; epilepsy and ischemic neuronal cell death (Grosshans et al.; 2002; Wenthold et al.; 2003; Carroll and Zukin; 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al.; 1989; Alvestad et al.; 2003; Snell et al.; 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al.; 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al.; 1996).
- Host:
- Rabbit
- Immunogen:
- Fusion protein from the N-terminus of the NR2C-subunit of rat NMDA receptor.
- Molecular Weight:
- ~140kDa
- Protein Details:
- Glutamate receptor ionotropic; NMDA 2C
- Purification:
- Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
