IL-36B Antibody - C-terminal
Product Sizes
0.1 mg
£652.00
OAPB01811-0.1MG
About this Product
- SKU:
- OAPB01811
- Additional Names:
- family of interleukin 1-eta;FIL1;FIL1 eta;FIL1-(ETA);FIL1H;FILI-(ETA);IL-1 eta;IL1-ETA;IL1F8;IL-1F8;IL1F8 (Canonical product IL-1F8a);IL-1F8 (FIL1-eta);IL1H2;IL-1H2;interleukin 1 family; member 8 (eta);interleukin-1 eta;interleukin-1 family member 8;interleukin-1 homolog 2;Interleukin-1 Superfamily e;interleukin-36 beta.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts; articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes; dendritic cells and indirectly on T-cells to drive tissue infiltration; cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage; T-cell; and neutrophil chemokines; such as CCL3; CCL4; CCL5; CCL2; CCL17; CCL22; CL20; CCL5; CCL2; CCL17; CCL22; CXCL8; CCL20 and CXCL1; and the production of proinflammatory cytokines such as TNF-alpha; IL-8 and IL-6.
- Gene Details:
- interleukin 36 beta
- Host:
- Rabbit
- Immunogen:
- IL-36B antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-36B. The immunogen is located within the last 50 amino acids of IL-36B.
- Isotype:
- IgG
- Molecular Weight:
- Predicted: 18 kDa Observed: 17 kDa
- Protein Details:
- Interleukin-36 beta|interleukin-36 beta isoform 1 [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
