DIS3 Antibody - N-terminal
Product Sizes
0.1 mg
£652.00
OAPB01756-0.1MG
About this Product
- SKU:
- OAPB01756
- Additional Names:
- 2810028N01Rik;DIS3 exosome endoribonuclease and 3'-5' exoribonuclease;DIS3 mitotic control homolog;dis3p;EXOSC11;exosome complex exonuclease RRP44;exosome component 11;KIAA1008;mitotic control protein dis3 homolog;Protein DIS3 homolog;ribosomal RNA-processing protein 44;RRP44.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus; the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA; snRNA and snoRNA; in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts; such as antisense RNA species and promoter-upstream transcripts (PROMPTs); and of mRNAs with processing defects; thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm; the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions; and in RNA surveillance pathways; preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
- Gene Details:
- DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease
- Host:
- Rabbit
- Immunogen:
- DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.
- Isotype:
- IgG
- Molecular Weight:
- Predicted: 105 kDa Observed: 103 kDa
- Protein Details:
- Exosome complex exonuclease RRP44|exosome complex exonuclease RRP44 isoform a [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
