MYT1L Antibody - C-terminal
Product Sizes
0.1 mg
£652.00
OAPB01667-0.1MG
About this Product
- SKU:
- OAPB01667
- Additional Names:
- MRD39;myelin transcription factor 1-like protein;myT1-L;neural zinc finger transcription factor 1;NZF1;ZC2H2C2;ZC2HC4B.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages; mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis; such as members of the Notch signaling pathway; including HES1. The combination of three transcription factors; ASCL1; POU3F2/BRN2 and MYT1L; is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
- Gene Details:
- myelin transcription factor 1 like
- Host:
- Rabbit
- Immunogen:
- Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L. The immunogen is located within the last 50 amino acids of MYT1L.
- Isotype:
- IgG
- Molecular Weight:
- 130 kDa
- Protein Details:
- Myelin transcription factor 1-like protein|myelin transcription factor 1-like protein isoform 2 [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
