PHLPP2 Antibody - C-terminal
Product Sizes
0.1 mg
£652.00
OAPB01641-0.1MG
About this Product
- SKU:
- OAPB01641
- Additional Names:
- PH domain leucine-rich repeat-containing protein phosphatase 2;PH domain leucine-rich repeat-containing protein phosphatase-like;PHLPPL;PPM3B;protein phosphatase; Mg2+/Mn2+ dependent 3B.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1; 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).
- Gene Details:
- PH domain and leucine rich repeat protein phosphatase 2
- Host:
- Rabbit
- Immunogen:
- PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2. The immunogen is located within the last 50 amino acids of PHLPP2.
- Isotype:
- IgG
- Molecular Weight:
- 156 kDa
- Protein Details:
- PH domain leucine-rich repeat-containing protein phosphatase 2|PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1 [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
