APH1 Antibody - N-terminal
Product Sizes
0.1 mg
£652.00
OAPB01427-0.1MG
About this Product
- SKU:
- OAPB01427
- Additional Names:
- 6530402N02Rik;anterior pharynx defective 1 homolog A;APH-1;APH-1A;APH1A gamma secretase subunit;aph-1alpha;CGI-78;gamma-secretase subunit APH-1A;presenilin-stabilization factor.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Non-catalytic subunit of the gamma-secretase complex; an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508; PubMed:12522139; PubMed:12763021; PubMed:12679784; PubMed:25043039; PubMed:26280335). Required for normal gamma-secretase assembly (PubMed:12522139; PubMed:12471034; PubMed:12763021; PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins; and by regulating cytosolic CTNNB1 levels (Probable).
- Gene Details:
- aph-1 homolog A; gamma-secretase subunit
- Host:
- Rabbit
- Immunogen:
- APH1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human APH1. The immunogen is located within amino acids 80 - 130 of APH1.
- Isotype:
- IgG
- Molecular Weight:
- Predicted: 29 kDa Observed: 28 kDa
- Protein Details:
- Anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens]|Gamma-secretase subunit APH-1A
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
