TMP21 Antibody - N-terminal
Product Sizes
0.1 mg
£652.00
OAPB01426-0.1MG
About this Product
- SKU:
- OAPB01426
- Additional Names:
- 21 kDa transmembrane trafficking protein;21 kDa transmembrane-trafficking protein;p23;p24 family protein delta-1;P24(DELTA);p24d1;p24delta;p24delta1;S31I125;S31III125;testicular tissue protein Li 206;TMP21;Tmp-21-I;transmembrane emp24 domain-containing protein 10;transmembrane emp24-like trafficking protein 10;transmembrane protein Tmp21.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes; acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1; OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.
- Gene Details:
- transmembrane p24 trafficking protein 10
- Host:
- Rabbit
- Immunogen:
- TMP21 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TMP21. The immunogen is located within amino acids 70 - 120 of TMP21.
- Isotype:
- IgG
- Protein Details:
- TMP21 [Homo sapiens]|Transmembrane emp24 domain-containing protein 10
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
