BOK Antibody - N-terminal
Product Sizes
0.1 mg
£652.00
OAPB01421-0.1MG
About this Product
- SKU:
- OAPB01421
- Additional Names:
- BCL2 related ovarian killer;bcl2-L-9;BCL2L9;bcl-2-like protein 9;bcl-2-related ovarian killer protein;BOK; BCL2 family apoptosis regulator;BOKL;hBOK.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518; PubMed:15102863; PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518; PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization; in a BAX- and BAK1-independent manner; in response to inhibition of ERAD-proteasome degradation system; resulting in cytochrome c release (PubMed:27076518). In response to DNA damage; mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process; by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis; may regulate trophoblast cell proliferation during the early stages of placental development; by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
- Gene Details:
- BCL2 family apoptosis regulator BOK
- Host:
- Rabbit
- Immunogen:
- BOK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BOK. The immunogen is located within the first 50 amino acids of BOK.
- Isotype:
- IgG
- Protein Details:
- Bcl-2-related ovarian killer protein|BOK protein [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
