CD4 Antibody
Product Sizes
0.1 mg
£712.00
OAPB01359-0.1MG
About this Product
- SKU:
- OAPB01359
- Additional Names:
- CD4 antigen (p55);CD4 receptor;CD4mut;IMD79;OKT4D;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4.
- Clonality:
- Monoclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells; plays a role in differentiation/activation; cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Gene Details:
- CD4 molecule
- Immunogen:
- Mouse monoclonal CD4 antibody (PM-5203) was raised against a 193 amino acid recombinant protein near the amino terminus of human CD4.
- Molecular Weight:
- Predicted: 51kD Observed: 51 kD
- Protein Details:
- T-cell surface glycoprotein CD4|T-cell surface glycoprotein CD4 isoform 1 precursor [Homo sapiens]
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- CD4 monoclonal antibody can be stored at 4C; stable for one year.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
