C-raf Antibody
Product Sizes
0.1 mg
£652.00
OAPB01117-0.1MG
About this Product
- SKU:
- OAPB01117
- Additional Names:
- CMD1NN;c-Raf;CRAF;C-Raf proto-oncogene; serine/threonine kinase;NS5;Oncogene RAF1;proto-oncogene c-RAF;raf proto-oncogene serine/threonine protein kinase;RAF proto-oncogene serine/threonine-protein kinase;Raf-1;v-raf-1 murine leukemia viral oncogene homolog 1;v-raf-1 murine leukemia viral oncogene-like protein 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade; and this critical regulatory link functions as a switch determining cell fate decisions including proliferation; differentiation; apoptosis; survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339; by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2; ADCY5 and ADCY6; resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2); apoptosis (MAP3K5/ASK1 and STK3/MST2); proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration; and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein; occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG; which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli; notably Fas stimulation; pathogen-mediated macrophage apoptosis; and erythroid differentiation.
- Gene Details:
- Raf-1 proto-oncogene; serine/threonine kinase
- Immunogen:
- C-raf antibody was raised against an 19 amino acid synthetic peptide near the amino terminus of human C-raf. The immunogen is located within amino acids 30 - 80 of C-raf.
- Molecular Weight:
- Predicted: 72 kDa Observed: 72 kDa
- Protein Details:
- RAF proto-oncogene serine/threonine-protein kinase|RAF proto-oncogene serine/threonine-protein kinase isoform b [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- C-raf antibody can be stored at 4C; stable for three months. Store at -20C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
