Aak1 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00768-0.1MG
About this Product
- SKU:
- OAPB00768
- Additional Names:
- adaptor-associated kinase 1;AP2-associated protein kinase 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization; promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1; increases its localization in endosomes and regulates its transcriptional activity.
- Gene Details:
- AP2 associated kinase 1
- Host:
- Rabbit
- Immunogen:
- Aak1 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of the human Aak1. The immunogen is located within amino acids 190 - 240 of Aak1.
- Protein Details:
- AP2-associated protein kinase 1|AP2-associated protein kinase 1 [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Aak1 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
