BRSK2 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00510-0.1MG
About this Product
- SKU:
- OAPB00510
- Additional Names:
- BR serine/threonine-protein kinase 2;brain-selective kinase 2;brain-specific serine/threonine-protein kinase 2;C11orf7;PEN11B;protein kinase SAD1B;SAD1;SADA;serine/threonine-protein kinase 29;serine/threonine-protein kinase BRSK2;serine/threonine-protein kinase SAD-A;STK29;testicular tissue protein Li 30.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis; cell cycle progress and insulin secretion. Phosphorylates CDK16; CDC25C; MAPT/TAU; PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1; acts as a key regulator of polarization of cortical neurons; probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons; leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels; probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068); BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
- Gene Details:
- BR serine/threonine kinase 2
- Host:
- Rabbit
- Immunogen:
- BRSK2 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human BRSK2. The immunogen is located within amino acids 630 - 680 of BRSK2.
- Protein Details:
- Serine/threonine-protein kinase BRSK2
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- BRSK2 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
