TIGAR Antibody
Product Sizes
0.1 mg
£652.00
OAPB00495-0.1MG
About this Product
- SKU:
- OAPB00495
- Additional Names:
- C12orf5;FR2BP;fructose-2;6-bisphosphatase TIGAR;fructose-2;6-bisphosphate 2-phosphatase;probable fructose-2;6-bisphosphatase TIGAR;TP53-induced glycolysis and apoptosis regulator;TP53-induced glycolysis regulatory phosphatase;transactivated by NS3TP2 protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Fructose-bisphosphatase hydrolyzing fructose-2;6-bisphosphate as well as fructose-1;6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2;6-bisphosphate in a p53/TP53-dependent manner; resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880; PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content; correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880; PubMed:19713938; PubMed:23726973; PubMed:22887998; PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress; mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death; and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth; proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).
- Gene Details:
- TP53 induced glycolysis regulatory phosphatase
- Host:
- Rabbit
- Immunogen:
- TIGAR antibody was raised against a 18 amino acid synthetic peptide from near the center of human TIGAR. The immunogen is located within amino acids 60 - 110 of TIGAR.
- Protein Details:
- Fructose-2;6-bisphosphatase TIGAR|fructose-2;6-bisphosphatase TIGAR [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- TIGAR antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
