CD5L Antibody
Product Sizes
0.1 mg
£652.00
OAPB00411-0.1MG
About this Product
- SKU:
- OAPB00411
- Additional Names:
- AIM;API6;apoptosis inhibitor 6;apoptosis inhibitor expressed by macrophages;apoptosis inhibitor of macrophage;CD5 antigen-like;CD5 antigen-like (scavenger receptor cysteine rich family);CT-2;hAIM;igM-associated peptide;PRO229;Spalpha;SP-ALPHA.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses; such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis; associates with cytosolic FASN; inhibiting fatty acid synthase activity and leading to lipolysis; the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues; a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC; the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells; where it decreases the content of polyunsaturated fatty acyls (PUFA); affecting two metabolic proteins MSMO1 and CYP51A1; which synthesize ligands of RORC; limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM; interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018; PubMed:24223991; PubMed:24583716; PubMed:25713983).
- Gene Details:
- CD5 molecule like
- Host:
- Rabbit
- Immunogen:
- AIM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human AIM. The immunogen is located within amino acids 60 - 110 of AIM.
- Isotype:
- IgG
- Protein Details:
- AIM [Homo sapiens]|CD5 antigen-like
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- AIM antibody can be stored at 4°C for three months and -20°C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
