TLR6 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00364-0.1MG
About this Product
- SKU:
- OAPB00364
- Additional Names:
- CD286;toll-like receptor 6.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and; to a lesser extent; triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides; forms the activation cluster TLR2:TLR6:CD14:CD36; this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2); soluble tuberculosis factor (STF); phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion (PubMed:11441107; PubMed:20037584).
- Gene Details:
- toll like receptor 6
- Host:
- Rabbit
- Immunogen:
- TLR6 antibody was raised against a peptide corresponding to 13 amino acids near the center of human TLR6. The immunogen is located within amino acids 390 - 440 of TLR6.
- Protein Details:
- Toll-like receptor 6|toll-like receptor 6 precursor [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- TLR6 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
