SARS-CoV-2 Spike Antibody
Product Sizes
0.1 mg
£652.00
OAPB00314-0.1MG
About this Product
- SKU:
- OAPB00314
- Additional Names:
- E2;GU280_gp02;Peplomer protein;spike glycoprotein;surface glycoprotein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Attaches the virion to the cell membrane by interacting with host receptor; initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651; PubMed:32221306; PubMed:32075877; PubMed:32155444). Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell (PubMed:33082294; PubMed:33082293). This interaction may explain virus tropism of human olfactory epithelium cells; which express high level of NRP1 and NRP2 but low level of ACE2 (PubMed:33082293). The stalk domain of S contains three hinges; giving the head unexpected orientational freedom (PubMed:32817270). Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Can be alternatively processed by host furin (PubMed:32362314). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.
- Gene Details:
- surface glycoprotein
- Host:
- Rabbit
- Immunogen:
- Anti-SARS-CoV-2 (COVID-19) Spike antibody (3525) was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of SARS-CoV-2 (COVID-19) Spike glycoprotein. The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19) Spike protein.
- Isotype:
- IgG
- Protein Details:
- Spike glycoprotein|surface glycoprotein [Severe acute respiratory syndrome coronavirus 2]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
