AGAP2 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00239-0.1MG
About this Product
- SKU:
- OAPB00239
- Additional Names:
- Arf GAP with GTP-binding protein-like; ANK repeat and PH domains 2;arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2;centaurin; gamma 1;Centaurin-gamma-1;CENTG1;GGAP2;GTP-binding and GTPase activating protein 2;GTP-binding and GTPase-activating protein 2;phosphatidylinositol 3-kinase enhancer;phosphoinositide 3-kinase enhancer;PIKE.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- GTPase-activating protein (GAP) for ARF1 and ARF5; which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins; and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells; prevents apoptosis and promotes cancer cell invasion.
- Gene Details:
- ArfGAP with GTPase domain; ankyrin repeat and PH domain 2
- Host:
- Rabbit
- Immunogen:
- PIKE antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human PIKE. The immunogen is located within the last 50 amino acids of PIKE.
- Protein Details:
- Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2|PI 3-kinase enhancer long isoform [Homo sapiens]
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- PIKE antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
