ACE2 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00214-0.1MG
About this Product
- SKU:
- OAPB00214
- Additional Names:
- ACEH;ACE-related carboxypeptidase;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;angiotensin I converting enzyme 2;angiotensin-converting enzyme 2;angiotensin-converting enzyme homolog;angiotensin-converting enzyme-related carboxypeptidase;metalloprotease MPROT15;peptidyl-dipeptidase A;truncated angiotensin converting enzyme 2.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume; systemic vascular resistance; and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9; a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes; and angiotensin II to angiotensin 1-7; which then acts as a beneficial vasodilator and anti-proliferation agent; counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042; PubMed:10924499; PubMed:11815627; PubMed:19021774; PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides; neurotensin; kinetensin; and des-Arg bradykinin; but is not active on bradykinin (PubMed:10969042; PubMed:11815627). Also cleaves other biological peptides; such as apelins (apelin-13; [Pyr1]apelin-13; apelin-17; apelin-36); casomorphins (beta-casomorphin-7; neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627; PubMed:27217402; PubMed:28293165). In addition; ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction; regulating its expression on the cell surface and its catalytic activity (PubMed:18424768; PubMed:19185582).
- Gene Details:
- angiotensin converting enzyme 2
- Host:
- Rabbit
- Immunogen:
- Anti-ACE2 antibody (3217) was raised against a peptide corresponding to 18 amino acids near the carboxy terminus of human ACE2. The immunogen is located within the last 50 amino acids of ACE2.
- Isotype:
- IgG
- Molecular Weight:
- Predicted: 93kD Observed: 130 kD (7 N-linked glycosylation)
- Protein Details:
- Angiotensin-converting enzyme 2|angiotensin-converting enzyme 2 precursor [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
