BIRC7 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00156-0.1MG
About this Product
- SKU:
- OAPB00156
- Additional Names:
- baculoviral IAP repeat-containing protein 7;KIAP;kidney inhibitor of apoptosis protein;LIVIN;livin inhibitor of apoptosis;melanoma inhibitor of apoptosis protein;MLIAP;ML-IAP;RING finger protein 50;RING-type E3 ubiquitin transferase BIRC7;RNF50.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis; cell proliferation; and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3; CASP7 and CASP9; as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor; its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition; by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin; etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1; and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro; inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
- Gene Details:
- baculoviral IAP repeat containing 7
- Host:
- Rabbit
- Immunogen:
- Livin antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Livin. The immunogen is located within the last 50 amino acids of Livin.
- Molecular Weight:
- 33 kDa
- Protein Details:
- Baculoviral IAP repeat-containing protein 7|baculoviral IAP repeat-containing protein 7 isoform beta [Homo sapiens]
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Livin antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
