DR6 Antibody
Product Sizes
0.1 mg
£652.00
OAPB00077-0.1MG
About this Product
- SKU:
- OAPB00077
- Additional Names:
- BM-018;CD358;death receptor 6;DR6;TNFR-related death receptor 6;tumor necrosis factor receptor superfamily member 21.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Promotes apoptosis; possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis; including apoptosis in response to amyloid peptides derived from APP; and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival; maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors; in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4; IL5; IL10; IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG; IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
- Gene Details:
- TNF receptor superfamily member 21
- Host:
- Rabbit
- Immunogen:
- DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6. The immunogen is located within amino acids 30 - 80 of DR6.
- Molecular Weight:
- 68 kDa
- Protein Details:
- Homo sapiens TNFR-related death receptor-6 (DR6) mRNA; complete cds|Tumor necrosis factor receptor superfamily member 21
- Purification:
- Ion Exchange
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- DR6 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
