MADD Antibody
Product Sizes
0.1 mg
£652.00
OAPB00025-0.1MG
About this Product
- SKU:
- OAPB00025
- Additional Names:
- DEEAH;DENN;differentially expressed in normal and neoplastic cells;IG20;insulinoma glucagonoma clone 20;MAP kinase-activating death domain protein;NEDDISH;Rab3 GDP/GTP exchange factor;rab3 GDP/GTP exchange protein;RAB3GEP;RabGEF.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays a significant role in regulating cell proliferation; survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A; RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced; caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis; isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
- Gene Details:
- MAP kinase activating death domain
- Host:
- Rabbit
- Immunogen:
- MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD. The immunogen is located within the last 50 amino acids of MADD.
- Molecular Weight:
- 200 to 220 kDa
- Protein Details:
- DENN [Homo sapiens]|MAP kinase-activating death domain protein
- Purification:
- Ion Exchange
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- MADD antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
