HIV-1 gp41 Antibody
Product Sizes
0.5mg
£485.00
OAPA00058-0.5MG
About this Product
- SKU:
- OAPA00058
- Additional Names:
- HIV-1 gp41 antibody; HIV-1 gp41; Mouse antibody
- translate.label.attr.clone:
- NYRHIV1gp41.
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml (prior to lyophilization)
- Extra Details:
- Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail; leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells); macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly; direct viral killing of infected cells; secondly; increased rates of apoptosisin infected cells; and thirdly; killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level; cell-mediated immunityis lost; and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus; part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses; which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded; positive-sense; enveloped RNA viruses. Upon entry of the target cell; the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell; two pathways are possible: either the virus becomes latentand the infected cell continues to function; or the virus becomes active and replicates; and a large number of virus particles are liberated that can then infect other cells.
- Host:
- Mouse
- Immunogen:
- r.gp41.
- Isotype:
- Mouse IgG1.
- Protein Details:
- Envelope glycoprotein gp160
- Purity:
- Ion exchange column.
- Purification:
- Ion exchange column
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Reconstitute with H2O. Mix gently; wash the sides of the vial and wait 30-60 seconds before use. In lyophilized form; for long periods; store at 4°C in a dry environment. After reconstitution; if not intended for use within a month; aliquot and store at -20°C.
Shipping Conditions: Antibody is shipped lyophilized at ambient temperature. - Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
