C9ORF72 Antibody
Product Sizes
100ul
£630.00
OAGA08561-100UL
About this Product
- SKU:
- OAGA08561
- Additional Names:
- ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
- translate.label.attr.clone:
- GT779
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene plays an important role in the regulation of endosomal trafficking; and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA; and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Gene Details:
- chromosome 9 open reading frame 72
- Host:
- Mouse
- Immunogen:
- The immunogen used to generate this antibody corresponds to human C9orf72
- Isotype:
- IgG1
- Molecular Weight:
- 54 kDa
- Protein Details:
- guanine nucleotide exchange C9orf72
- Purification:
- Affinity purified by Protein G.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks); store at 4C. For long-term storage; aliquot and store at -20C or below. Avoid multiple freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
