C4A Antibody - N-terminal region
Product Sizes
100ul
£630.00
OAGA03578-100UL
About this Product
- SKU:
- OAGA03578
- Additional Names:
- C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2
- Clonality:
- Polyclonal
- Concentration:
- 0.52 mg/ml
- Extra Details:
- This gene encodes the acidic form of complement factor 4; part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha; beta; and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin; an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist; such that individuals may have 1; 2; or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
- Gene Details:
- complement C4A (Rodgers blood group)
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the N-terminus region of human C4. The exact sequence is proprietary.
- Isotype:
- IgG
- Protein Details:
- complement C4-A
- Purification:
- Purified by antigen-affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
