MAP3K3 Antibody
Product Sizes
100ul
£630.00
OAGA03078-100UL
About this Product
- SKU:
- OAGA03078
- Additional Names:
- MEKK3; MAPKKK3
- Clonality:
- Polyclonal
- Concentration:
- 0.71 mg/ml
- Extra Details:
- This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases; including mouse Mekk2; tobacco NPK; and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays; it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene; consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Gene Details:
- mitogen-activated protein kinase kinase kinase 3
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human MEKK3. The exact sequence is proprietary.
- Isotype:
- IgG
- Protein Details:
- mitogen-activated protein kinase kinase kinase 3
- Purification:
- Purified by antigen-affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
