AXIN2 Antibody - middle region
Product Sizes
100ul
£630.00
OAGA02539-100UL
About this Product
- SKU:
- OAGA02539
- Additional Names:
- AXIL; ODCRCS
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- The Axin-related protein; Axin2; presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway; like its rodent homologs; mouse conductin/rat axil. In mouse; conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon); beta-catenin; glycogen synthase kinase 3-beta; and conductin; which leads to the degradation of beta-catenin. Apparently; the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24; a region that shows frequent loss of heterozygosity in breast cancer; neuroblastoma; and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
- Gene Details:
- axin 2
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human axin 2. The exact sequence is proprietary.
- Isotype:
- IgG
- Purification:
- Purified by antigen-affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
