AIFM1 Antibody - N-terminal region
Product Sizes
100ul
£630.00
OAGA01908-100UL
About this Product
- SKU:
- OAGA01908
- Additional Names:
- AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; SEMDHL
- Clonality:
- Polyclonal
- Concentration:
- 0.72mg/ml
- Extra Details:
- This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells; and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition; this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6); a severe mitochondrial encephalomyopathy; as well as Cowchock syndrome; also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4); a disorder resulting in neuropathy; and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
- Gene Details:
- apoptosis-inducing factor; mitochondrion-associated; 1
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the N-terminus region of human AIF. The exact sequence is proprietary.
- Isotype:
- IgG
- Purification:
- Purified by antigen-affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
