CALM2 Antibody
Product Sizes
100ul
£630.00
OAGA01704-100UL
About this Product
- SKU:
- OAGA01704
- Additional Names:
- caM; CALM; CAM1; CAM3; CAMC; PHKD; CAMII; LQT15; PHKD2; CALML2; CAMIII
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein; but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways; cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665); while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497); a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10; 13; and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Gene Details:
- calmodulin 2 (phosphorylase kinase; delta)
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human Calmodulin 2. The exact sequence is proprietary.
- Isotype:
- IgG
- Purification:
- Purified by antigen-affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
