esxB Antibody
Product Sizes
0.1 mg (C100)
£398.00
OAEE01118-0.1MG
About this Product
- SKU:
- OAEE01118
- Additional Names:
- 10 kDa culture filtrate antigen CFP-10;cfp10;ESAT-6-like protein EsxB;lhp;Rv3874;Secreted antigenic protein MTSA-10.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817; PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner; monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca(2+) release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481).
- Gene Details:
- ESAT-6-like protein EsxB
- Host:
- Rabbit
- Immunogen:
- CFP10 (Rv3874) of Mycobacterium tuberculosis
- Protein Details:
- ESAT-6-like protein EsxB
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
