SLC3A2 Antibody
Product Sizes
100 tests (T100)
£441.00
OAEE01014-100TESTS
About this Product
- SKU:
- OAEE01014
- Additional Names:
- 4F2 light chain;4F2LC;CD98;CD98 light chain;D16S469E;E16;integral membrane protein E16;large neutral amino acids transporter small subunit 1;LAT1;L-type amino acid transporter 1;MPE16;sodium-independent neutral amino acid transporter LAT1;solute carrier family 7 (amino acid transporter light chain; L system); member 5;solute carrier family 7 (cationic amino acid transporter; y+ system); member 5;Solute carrier family 7 member 5;y+ system cationic amino acid transporter.
- translate.label.attr.clone:
- MEM-108
- Clonality:
- Monoclonal
- Conjugate:
- R-PE
- Concentration:
- 20 ul / test
- Extra Details:
- Sodium-independent; high-affinity transport of large neutral amino acids such as phenylalanine; tyrosine; leucine; arginine and tryptophan; when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier; and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D;L-homocysteine complexes; and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols; via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. When associated with LAPTM4B; recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).
- Gene Details:
- solute carrier family 7 member 5
- Host:
- Mouse
- Immunogen:
- RAJI human Burkitt's lymphoma cell line
- Isotype:
- IgG1
- Protein Details:
- Large neutral amino acids transporter small subunit 1
- Purification:
- Purified by size-exclusion chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
