CD8B Antibody
Product Sizes
0.1 mg (C100)
£366.00
OAEE00998-0.1MG
About this Product
- SKU:
- OAEE00998
- Additional Names:
- CD8 antigen; beta polypeptide 1 (p37);CD8B1;LEU2;LY3;LYT3;P37;T lymphocyte surface glycoprotein beta chain;T-cell surface glycoprotein CD8 beta chain.
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited; it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally; plays a critical role in thymic selection of CD8+ T-cells.
- Gene Details:
- CD8b molecule
- Host:
- Mouse
- Immunogen:
- CD8 positive Wistar rat splenic T cell hybridomas
- Isotype:
- IgG1
- Protein Details:
- T-cell surface glycoprotein CD8 beta chain
- Purification:
- Purified by size-exclusion chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
