CD4 Antibody
Product Sizes
100 tests (T100)
£441.00
OAEE00848-100TESTS
About this Product
- SKU:
- OAEE00848
- Additional Names:
- CD4 antigen (p55);CD4 receptor;CD4mut;IMD79;OKT4D;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4.
- translate.label.attr.clone:
- MEM-241
- Clonality:
- Monoclonal
- Conjugate:
- PerCP
- Concentration:
- 10 ul / test
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells; plays a role in differentiation/activation; cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Gene Details:
- CD4 molecule
- Host:
- Mouse
- Immunogen:
- 2 N-terminal domains of human CD4 fused to human IgG1 Fc
- Isotype:
- IgG1
- Protein Details:
- T-cell surface glycoprotein CD4
- Purification:
- Purified by size-exclusion chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
