ITGB2 Antibody
Product Sizes
0.1 mg (C100)
£337.00
OAEE00687-0.1MG
About this Product
- SKU:
- OAEE00687
- Additional Names:
- 2E6;AI528527;Cd18;cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta;complement receptor C3 subunit beta;integrin beta-2;LAD;LCAMB;Lfa1;lymphocyte function associated antigen 1;Mac-1 beta;macrophage antigen-1 beta;MF17.
- translate.label.attr.clone:
- M18/2
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Integrin ITGAL/ITGB2 is a receptor for ICAM1; ICAM2; ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (By similarity). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (By similarity). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3; contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). In association with alpha subunit ITGAM/CD11b; required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation; in response to a impaired degranulation and phagocytosis; events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.
- Gene Details:
- integrin beta 2
- Host:
- Rat
- Immunogen:
- Murine cytotoxic T cell glycoproteins
- Isotype:
- IgG2a
- Protein Details:
- Integrin beta-2
- Purification:
- Purified by size-exclusion chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
