EGFR Antibody
Product Sizes
0.1 mg (C100)
£376.00
OAEE00389-0.1MG
About this Product
- SKU:
- OAEE00389
- Additional Names:
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;cell growth inhibiting protein 40;cell proliferation-inducing protein 61;epidermal growth factor receptor;epidermal growth factor receptor tyrosine kinase domain;ERBB;ERBB1;erb-b2 receptor tyrosine kinase 1;ERRP;HER1;mENA;NISBD2;PIG61;proto-oncogene c-ErbB-1;receptor tyrosine-protein kinase erbB-1.
- translate.label.attr.clone:
- EGFR1
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960; PubMed:10805725; PubMed:27153536). Known ligands include EGF; TGFA/TGF-alpha; AREG; epigen/EPGN; BTC/betacellulin; epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960; PubMed:7679104; PubMed:8144591; PubMed:9419975; PubMed:15611079; PubMed:12297049; PubMed:27153536; PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity).
- Gene Details:
- epidermal growth factor receptor
- Host:
- Mouse
- Immunogen:
- Human epidermoid carcinoma line A431
- Isotype:
- IgG2b
- Protein Details:
- Epidermal growth factor receptor
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
