CD40 Antibody
Product Sizes
0.1 mg (C100)
£337.00
OAEE00230-0.1MG
About this Product
- SKU:
- OAEE00230
- Additional Names:
- B cell surface antigen CD40;B cell-associated molecule;Bp50;CD4 antigen;CD40 molecule; TNF receptor superfamily member 5;CD40L receptor;CDW40;p50;p55;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;TNFRSF5;tumor necrosis factor receptor superfamily member 5;W3/25;W3/25 antigen.
- translate.label.attr.clone:
- HI40a
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells; plays a role in differentiation/activation; cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Gene Details:
- Cd4 molecule|CD40 molecule
- Host:
- Mouse
- Immunogen:
- Human CD40a
- Isotype:
- IgG1
- Protein Details:
- T-cell surface glycoprotein CD4
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
