LAIR1 Antibody
Product Sizes
0.1 mg (C100)
£326.00
OAEE00200-0.1MG
About this Product
- SKU:
- OAEE00200
- Additional Names:
- CD305;immunoglobulin heavy chain variable region;LAIR-1;leukocyte-associated Ig-like receptor 1;leukocyte-associated immunoglobulin-like receptor 1.
- translate.label.attr.clone:
- NKTA255
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells; B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells; down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8; IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
- Gene Details:
- leukocyte associated immunoglobulin like receptor 1
- Host:
- Mouse
- Immunogen:
- Activated NK cells and CD3- thymocytes
- Isotype:
- IgG1
- Protein Details:
- Leukocyte-associated immunoglobulin-like receptor 1
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
