Cd3e Antibody
Product Sizes
0.1 mg (C100)
£225.00
OAEE00194-0.1MG
About this Product
- SKU:
- OAEE00194
- Additional Names:
- AI504783;CD3;CD3epsilon;T3e;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain.
- translate.label.attr.clone:
- 145-2C11
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation; CD3E plays an essential role in correct T-cell developement (PubMed:19956738; PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
- Gene Details:
- CD3 antigen; epsilon polypeptide
- Host:
- Hamster
- Immunogen:
- Mouse BM10-37 cytotoxic T lymphocytes
- Isotype:
- IgG
- Protein Details:
- T-cell surface glycoprotein CD3 epsilon chain
- Purification:
- Purified by size-exclusion chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
