CD177 Antibody
Product Sizes
0.1 mg (C100)
£337.00
OAEE00116-0.1MG
About this Product
- SKU:
- OAEE00116
- Additional Names:
- CD177 antigen;cell surface receptor;HNA-2a;HNA2A;human neutrophil alloantigen 2a;NB1;NB1 glycoprotein;NB1 GP;polycythemia rubra vera protein 1;PRV1;PRV-1.
- translate.label.attr.clone:
- MEM-166
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18; mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition; by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However; appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676; PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface; may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
- Gene Details:
- CD177 molecule
- Host:
- Mouse
- Immunogen:
- Human granulocytes
- Isotype:
- IgG1
- Protein Details:
- CD177 antigen
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
