KLRB1 Antibody
Product Sizes
0.1 mg (C100)
£326.00
OAEE00111-0.1MG
About this Product
- SKU:
- OAEE00111
- Additional Names:
- CD161;CLEC5B;C-type lectin domain family 5 member B;hNKR-P1A;killer cell lectin-like receptor subfamily B member 1;killer cell lectin-like receptor subfamily B; member 1;natural killer cell surface protein P1A;NKR;NKR-P1;NKRP1A;NKR-P1A.
- translate.label.attr.clone:
- HP-3G10
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1;3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
- Gene Details:
- killer cell lectin like receptor B1
- Host:
- Mouse
- Immunogen:
- human NK cells
- Isotype:
- IgG1
- Protein Details:
- Killer cell lectin-like receptor subfamily B member 1
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
