FLT3 Antibody
Product Sizes
0.1 mg (C100)
£326.00
OAEE00078-0.1MG
About this Product
- SKU:
- OAEE00078
- Additional Names:
- CD135;CD135 antigen;fetal liver kinase 2;Fetal liver kinase-2;FL cytokine receptor;FLK2;FLK-2;fms related tyrosine kinase 3;fms-like tyrosine kinase 3;growth factor receptor tyrosine kinase type III;receptor-type tyrosine-protein kinase FLT3;stem cell tyrosine kinase 1;STK1.
- translate.label.attr.clone:
- BV10A4
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation; proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1; and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases; including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES; FER; PTPN6/SHP; PTPN11/SHP-2; PLCG1; and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Gene Details:
- fms related receptor tyrosine kinase 3
- Host:
- Mouse
- Immunogen:
- BV-173 leukemic cell line
- Isotype:
- IgG1
- Protein Details:
- Receptor-type tyrosine-protein kinase FLT3
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
