KIT Antibody
Product Sizes
0.1 mg (C100)
£326.00
OAEE00056-0.1MG
About this Product
- SKU:
- OAEE00056
- Additional Names:
- CD117;C-Kit;c-Kit protooncogene;mast/stem cell growth factor receptor Kit;MASTC;p145 c-kit;PBT;piebald trait protein;proto-oncogene c-Kit;proto-oncogene tyrosine-protein kinase Kit;SCFR;soluble KIT variant 1;tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein.
- translate.label.attr.clone:
- 104D2
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation; hematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis. In response to KITLG/SCF binding; KIT can activate several signaling pathways. Phosphorylates PIK3R1; PLCG1; SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS; RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1; STAT3; STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. KIT signaling is modulated by protein phosphatases; and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU; and of the transcription factors STAT1; STAT3; STAT5A and STAT5B. Promotes phosphorylation of PIK3R1; CBL; CRK (isoform Crk-II); LYN; MAPK1/ERK2 and/or MAPK3/ERK1; PLCG1; SRC and SHC1.
- Gene Details:
- KIT proto-oncogene; receptor tyrosine kinase
- Host:
- Mouse
- Immunogen:
- MOLM-1 megakaryocytic cells
- Isotype:
- IgG1
- Protein Details:
- Mast/stem cell growth factor receptor Kit
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
