LAMP2 Antibody
Product Sizes
0.1 mg (C100)
£326.00
OAEE00053-0.1MG
About this Product
- SKU:
- OAEE00053
- Additional Names:
- CD107 antigen-like family member B;CD107b;DND;LAMP-2;LAMPB;LGP110;LGP-96;lysosome-associated membrane glycoprotein 2.
- translate.label.attr.clone:
- H4B4
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays an important role in chaperone-mediated autophagy; a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539; PubMed:11082038; PubMed:18644871; PubMed:24880125; PubMed:27628032). Functions by binding target proteins; such as GAPDH and MLLT11; and targeting them for lysosomal degradation (PubMed:8662539; PubMed:11082038; PubMed:18644871; PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8; but fail to accumulate STX17 on autophagosomes; which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
- Gene Details:
- lysosomal associated membrane protein 2
- Host:
- Mouse
- Immunogen:
- Human PBMC
- Isotype:
- IgG1
- Protein Details:
- Lysosome-associated membrane glycoprotein 2
- Purity:
- > 95% (by SDS-PAGE)
- Purification:
- Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
